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Bone Graft
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WEGO DENTAL IMPLANT SYSTEM
Bone Graft
RuiBang Biomaterials Co., Ltd., a subsidiary of WEGO Medical, successfully expressed rhBMP-2 in prokaryotic organisms using genetic engineering technology.
Through specific techniques, we have achieved a purity of over 95% with a dimeric structure, high bone inductivity, and stability of rhBMP-2. Furthermore, we have attained a pilot production capacity of 30 mg per batch of rhBMP-2.
Overview
RuiBang Biomaterials Co., Ltd., a subsidiary of WEGO Medical, successfully expressed rhBMP-2 in prokaryotic organisms using genetic engineering technology.
Through specific techniques, we have achieved a purity of over 95% with a dimeric structure, high bone inductivity, and stability of rhBMP-2. Furthermore, we have attained a pilot production capacity of 30 mg per batch of rhBMP-2.
The oral bone powder product, ChiTai, from Shanghai RuiBang Biomaterials, utilizes advanced technology to load rhBMP-2. It is the only oral bone powder product in China that truly possesses bone conduction and bone induction properties by carrying BMP growth factors.
Specifications
Specification
| RB-a-SK-1V (approximately 0.5g) |
| RB-a-SK-1/2V(approximately0.25g) |
| RB-a-SK-1/4V(approximately0.125g) |
| RB-a-SK-005G |
Feature
It has a three-dimensional structure with interconnected pores and uniform pore size. |
Using a new generation of bone inductivity materials. |
Promoting bone regeneration to ensure sufficient conditions for dental implantation in the alveolar bone. |
| Compatible with the use of rhBMP-2, accelerating bone healing. |
| On average, it reduces bone healing time by approximately 1-2 months compared to similar bone powder products. |
Advantage
The bone morphogenetic protein (BMP-2), loaded onto bone morphogenic protein (BMP) carriers, can actively induce undifferentiated mesenchymal stem cells in the body to transform into osteoblasts. This can shorten the bone healing time by approximately 2 months compared to using calf bone or allograft bone, and it results in higher bone quality. This is particularly beneficial for patients with large bone defects or poor bone conditions. |
This belongs to the internationally leading third-generation bone substitute materials. Currently available products on the market (including Gelfoam) only serve as scaffolds and possess bone conductivity. The next generation of products combines both bone conduction and bone induction, representing the future trend of bone powder development. |
The only product in China to obtain NMPA (National Medical Products Administration) registration certificate with active factors. |
The BMP-2 product was first launched in the United States in 2002 and has been used for orthopedic and maxillofacial surgery indications. It is safe, effective, and technologically mature. |
What is BMP-2?
| BMP-2 is a bone morphogenetic protein that acts as a growth factor. It has the ability to induce undifferentiated mesenchymal stem cells to differentiate and proliferate into chondrocytes and osteoblasts, promoting the maturation of osteoblasts. It is involved in the growth, development, and reconstruction of bone and cartilage, thereby accelerating the repair of bone defects. |
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